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Article

TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2014

Silwal-Pandit Laxmi, Vollan Hans Kristian Moen, Chin Suet-Feung, Rueda Oscar M, McKinney Steven, Osako Tomo, Quigley David A, Kristensen Vessela N, Aparicio Samuel, Børresen-Dale Anne-Lise, Caldas Carlos, Langerød Anita

Abstract excerpt

PURPOSE: In breast cancer, the TP53 gene is frequently mutated and the mutations have been associated with poor prognosis. The prognostic impact of the different types of TP53 mutations across the different molecular subtypes is still poorly understood. Here, we characterize the spectrum and prognostic significance of TP53 mutations with respect to the PAM50 subtypes and integrative clusters (IC). EXPERIMENTAL...

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PMID: 24803582
DOI: 10.1158/1078-0432.CCR-13-2943

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MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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