Article
Multidimensional quantitative phenotypic and molecular analysis reveals neomorphic behaviors of p53 missense mutants
29 Sept 2023
Abstract excerpt
Mutations in the TP53 tumor suppressor gene occur in >80% of the triple-negative or basal-like breast cancer. To test whether neomorphic functions of specific TP53 missense mutations contribute to phenotypic heterogeneity, we characterized phenotypes of non-transformed MCF10A-derived cell lines expressing the ten most common missense mutant p53 proteins and observed a wide spectrum of phenotypic changes in cell...
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