Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Monoallelic silencing and haploinsufficiency in early murine intestinal neoplasms.

Proceedings of the National Academy of Sciences of the United States of America - 7 Feb 2012

Amos-Landgraf James M, Irving Amy A, Hartman Cory, Hunter Anthony, Laube Brianna, Chen Xiaodi, Clipson Linda, Newton Michael A, Dove William F

Abstract excerpt

Studies of tumors from human familial adenomatous polyposis, sporadic colon cancer, and mouse and rat models of intestinal cancer indicate that the majority of early adenomas develop through loss of normal function of the Adenomatous polyposis coli (APC) gene. In murine models of familial adenomatous polyposis, specifically the multiple intestinal neoplasia mouse (Min) and the polyposis in the rat colon (Pirc)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Dosage

Share to Gene Silencing

Share to Genes, APC

Share to Genetic Loci

Share to Haploinsufficiency

Share to Intestinal Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 22308460
DOI: 10.1073/pnas.1120753109
PMCID: PMC3277532

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Monoallelic silencing and haploinsufficiency in early murine intestinal neoplasms.PMID 22308460Read ↗

Epigenetic loss of heterozygosity of Apc and an inflammation-associated mutational signature detected in Lrig1+/--driven murine colonic adenomas.Semantic proximity Read ↗

Intestinal adenomas can develop with a stable karyotype and stable microsatellitesSemantic proximity Read ↗

Epigenetic loss of heterozygosity of <i>Apc</i> and an inflammation-associated mutational signature detected in <i>Lrig1</i> <sup>+/-</sup> -driven murine colonic adenomasSemantic proximity Read ↗

A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis.Semantic proximity Read ↗

Loss of heterozygosity in human aberrant crypt foci (ACF), a putative precursor of colon cancer.Semantic proximity Read ↗

Genetic and epigenetic changes in the APC gene in sporadic colorectal carcinoma with synchronous adenoma.Semantic proximity Read ↗

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.Semantic proximity Read ↗

Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesisSemantic proximity Read ↗

Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human.Semantic proximity Read ↗

Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function.Semantic proximity Read ↗

Understanding phenotypic variation in rodent models with germline Apc mutations.Semantic proximity Read ↗

Loss of heterozygosity in spontaneous and x-ray-induced intestinal tumors arising in F1 hybridMin mice: Evidence for sequential loss ofApc+ andDpc4 in tumor developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.