Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic loss of heterozygosity of Apc and an inflammation-associated mutational signature detected in Lrig1+/--driven murine colonic adenomas.

BMC cancer - 14 Feb 2020

Preston Jessica L, Stiffler Nicholas

Abstract excerpt

BACKGROUND: The loss of a single copy of adenomatous polyposis coli (Apc) in leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1)-expressing colonic progenitor cells induces rapid growth of adenomas in mice with high penetrance and multiplicity. The tumors lack functional APC, and a genetic loss of heterozygosity of Apc was previously observed. METHODS: To identify genomic features of early...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Gene Silencing

Share to Genes, APC

Share to Loss of Heterozygosity

Share to Membrane Glycoproteins

Source

Open in PubMed Open full text

Identifiers

PMID: 32059662
DOI: 10.1186/s12885-020-6616-y
PMCID: PMC7023705

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic loss of heterozygosity of Apc and an inflammation-associated mutational signature detected in Lrig1+/--driven murine colonic adenomas.PMID 32059662Read ↗

Epigenetic loss of heterozygosity of <i>Apc</i> and an inflammation-associated mutational signature detected in <i>Lrig1</i> <sup>+/-</sup> -driven murine colonic adenomasSemantic proximity Read ↗

The landscape of somatic mutation in normal colorectal epithelial cellsSemantic proximity Read ↗

Inducible loss of one Apc allele in Lrig1-expressing progenitor cells results in multiple distal colonic tumors with features of familial adenomatous polyposisSemantic proximity Read ↗

Monoallelic silencing and haploinsufficiency in early murine intestinal neoplasms.Semantic proximity Read ↗

Mutational Landscape of Colorectal Tumors From Individuals With Unexplained Adenomatous or Serrated Colorectal Polyposis.Semantic proximity Read ↗

Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancersSemantic proximity Read ↗

The landscape of somatic mutation in normal colorectal epithelial cells.Semantic proximity Read ↗

Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome.Semantic proximity Read ↗

Multi-omic study of genome-edited human colonoid models of colorectal cancer reveal genotype-specific patterns of microRNA regulationSemantic proximity Read ↗

The earliest stages of neoplastic transformation in Familial Adenomatous PolyposisSemantic proximity Read ↗

DNA methylation analysis of normal colon organoids from familial adenomatous polyposis patients reveals novel insight into colon cancer developmentSemantic proximity Read ↗

Somatic inflammatory gene mutations in human ulcerative colitis epithelium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.