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Article

Interstitial deletion of the Apc locus in β-catenin-overexpressing cells is a signature of radiation-induced intestinal tumors in C3B6F1 ApcMin/+ mice†.

Journal of radiation research - 25 May 2023

Yanagihara Hiromi, Morioka Takamitsu, Yamazaki Shunsuke, Yamada Yutaka, Tachibana Hirotaka, Daino Kazuhiro, Tsuruoka Chizuru, Amasaki Yoshiko, Kaminishi Mutsumi, Imaoka Tatsuhiko, Kakinuma Shizuko

Abstract excerpt

Recent studies have identified interstitial deletions in the cancer genome as a radiation-related mutational signature, although most of them do not fall on cancer driver genes. Pioneering studies in the field have indicated the presence of loss of heterozygosity (LOH) spanning Apc in a subset of sporadic and radiation-induced intestinal tumors of ApcMin/+ mice, albeit with a substantial subset in which LOH was...

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Identifiers

PMID: 37117033
DOI: 10.1093/jrr/rrad021
PMCID: PMC10215001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interstitial deletion of the Apc locus in β-catenin-overexpressing cells is a signature of radiation-induced intestinal tumors in C3B6F1 ApcMin/+ mice†.PMID 37117033Read ↗

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