Mutational Profiles Reveal an Aberrant TGF-β-CEA Regulated Pathway in Colon Adenomas.

doi:10.1371/journal.pone.0153933

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Article

Mutational Profiles Reveal an Aberrant TGF-β-CEA Regulated Pathway in Colon Adenomas.

PloS one - 1 Jan 2016

Chen Jian, Raju Gottumukkala S, Jogunoori Wilma, Menon Vipin, Majumdar Avijit, Chen Jiun-Sheng, Gi Young Jin, Jeong Yun Seong, Phan Liem, Belkin Mitchell, Gu Shoujun, Kundra Suchin, Mistry Nipun A, Zhang Jianping, Su Xiaoping, Li Shulin, Lin Sue-Hwa, Javle Milind, McMurray John S, Rahlfs Thomas F, Mishra Bibhuti, White Jon, Rashid Asif, Beauchemin Nicole, Weston Brian R, Shafi Mehnaz A, Stroehlein John R, Davila Marta, Akbani Rehan, Weinstein John N, Wu Xifeng, Mishra Lopa

Abstract excerpt

Mutational processes and signatures that drive early tumorigenesis are centrally important for early cancer prevention. Yet, to date, biomarkers and risk factors for polyps (adenomas) that inordinately and rapidly develop into colon cancer remain poorly defined. Here, we describe surprisingly high mutational profiles through whole-genome sequence (WGS) analysis in 2 of 4 pairs of benign colorectal adenoma tissue...

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PMID: 27100181
DOI: 10.1371/journal.pone.0153933
PMCID: PMC4839765

Genes

TGFBR1

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