Article

<i>VHL</i> Synthetic Lethality Signatures Uncovered by Genotype-specific CRISPR-Cas9 Screens

2019-03-26

Abstract excerpt

<h4>Background</h4> Genome-wide CRISPR-Cas9 essentiality screening represents a powerful approach to identify genetic vulnerabilities in cancer cells. Here, we applied this technology and designed a strategy to identify target genes that are synthetic lethal (SL) with von Hippel-Lindau ( VHL ) tumor suppressor gene. Inactivation of VHL has been frequently found in clear cell renal cell carcinoma (ccRCC). Its S...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a6d7b1ce-6897-50cc-ba34-31350fd8a98a
DOI: 10.1101/588707

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>VHL</i> Synthetic Lethality Signatures Uncovered by Genotype-specific CRISPR-Cas9 ScreensDOI 10.1101/588707Read

Discovery of synthetic lethal and tumor suppressive paralog pairs in the human genomeSemantic proximity Read

CRISPR-enabled genetic screens identify synthetic lethal targets across frequently altered cancer driversSemantic proximity Read

MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens.Semantic proximity Read

CRISPR/Cas9-based discovery of ccRCC therapeutic opportunities through molecular mechanism and immune microenvironment analysisSemantic proximity Read

The puzzling case of the 3p25 homozygous deletion: the target is not <i>VHL</i> but <i>VGLL4</i> and <i>ATG7</i>Semantic proximity Read

Mechanisms of resistance to VHL loss-induced genetic and pharmacological vulnerabilitiesSemantic proximity Read

Application of CRISPR/Cas9 screening to study cancer drivers and to identify novel cancer vulnerabilitiesSemantic proximity Read

Mutations in tumor suppressor genes Vhl and Rassf1a cause DNA damage, chromosomal instability and induce gene expression changes characteristic of clear cell renal cell carcinomaSemantic proximity Read

Tumorigenesis Mechanisms Found in Hereditary Renal Cell Carcinoma: A ReviewSemantic proximity Read

Renal medullary carcinomas depend upon <i>SMARCB1</i> loss and are sensitive to proteasome inhibitionSemantic proximity Read

An Isogenic Cell Line Panel for Sequence-based Screening of Targeted Anti-cancer DrugsSemantic proximity Read

CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions.Semantic proximity Read