Article

Expanding RNA editing toolkit using an IDR-based strategy

2023-12-23

Abstract excerpt

<h4>ABSTRACT</h4> RNA base editors should ideally be free of immunogenicity, compact, efficient and specific, which has not been achieved for C>U editing. Here we first describe a compact C>U editor entirely of human origin, created by fusing the human C>U editing enzyme RESCUE-S to CIRTS, a tiny, human-originated programmable RNA binding domain. This editor, CIRTS-RESCUEv1 (V1), was inefficient. Remarkably, a sh...

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Literature Corpus work: 09bba4ff-2c32-5ff2-91a8-a6d90164def1
DOI: 10.1101/2023.12.23.573192

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