Article

A Toxic RNA Catalyzes the Cellular Synthesis of Its Own Inhibitor, Shunting It to Endogenous Decay Pathways

2019-08-21

Abstract excerpt

<h4>SUMMARY</h4> Myotonic dystrophy type 2 (DM2) is a genetically defined muscular dystrophy caused by a toxic expanded repeat of r(CCUG) [heretofore (CCUG) exp ], harbored in intron 1 of CHC-Type Zinc Finger Nucleic Acid Binding Protein ( CNBP ) pre-mRNA. This r(CCUG) exp causes DM2 via a gain-of-function mechanism that results in three hallmarks of its pathology: (i) binding to RNA-binding proteins (RBPs) th...

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Literature Corpus work: 0884c47a-17d8-55df-b132-d04a7c86849f
DOI: 10.1101/741926

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