Article

Development of B-to-A base editors by leveraging translesion synthesis polymerase

2025-07-28

Abstract excerpt

<title>Abstract</title> <p>Base editing technology enables single-nucleotide conversions without donor templates or DNA double-strand breaks (DSBs), yet current base editors lack the capacity to efficiently address C-to-A, G-to-A, or T-to-A conversion. Here we report the development of B-to-A base editors (BABEs, B=C/G/T) through co-expressing certain glycosylase-based base editors together with the engineered tr...

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Identifiers and source

Literature Corpus work: 90165653-78a9-56c8-badf-b006b02893e5
DOI: 10.21203/rs.3.rs-7122028/v1

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