Article

The YTHDC1 glutamate-rich domain docks to the ADAR1 Zα Domain, linking the N <sup>6</sup> -methyladenosine modification of pre-mRNAs to dsRNA editing

2026-07-12

Abstract excerpt

The p150 isoform of the double-stranded RNA editing enzyme ADAR1 binds Z-DNA and Z-RNA through the conserved winged helix-turn-helix Zα domain. Here, we describe an inverse computational design strategy to map protein interactors of Zα. We used RFdiffusion and ProteinMPNN to generate ∼10,000 synthetic binders optimized for the Zα recognition surface, then used their sequences as structural templates for BLASTp sea...

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Literature Corpus work: 0467334a-d89d-55b1-a6d6-04865a9220c9
DOI: 10.64898/2026.07.08.737312

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