Article
Structural plasticity of Cid1 provides a basis for its distributive RNA terminal uridylyl transferase activity.
Nucleic acids research - 11 Mar 2015
Yates Luke A, Durrant Benjamin P, Fleurdépine Sophie, Harlos Karl, Norbury Chris J, Gilbert Robert J C
Abstract excerpt
Terminal uridylyl transferases (TUTs) are responsible for the post-transcriptional addition of uridyl residues to RNA 3' ends, leading in some cases to altered stability. The Schizosaccharomyces pombe TUT Cid1 is a model enzyme that has been characterized structurally at moderate resolution and provides insights into the larger and more complex mammalian TUTs, ZCCHC6 and ZCCHC11. Here, we report a higher...
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