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Article

Physiologically relevant acid-sensing ion channel (ASIC) 2a/3 heteromers have a 1:2 stoichiometry.

Communications biology - 8 Jul 2023

Fischer Leon, Schmidt Axel, Dopychai Anke, Joussen Sylvia, Joeres Niko, Oslender-Bujotzek Adrienne, Schmalzing Günther, Gründer Stefan

Abstract excerpt

Acid-sensing ion channels (ASICs) sense extracellular protons and are involved in synaptic transmission and pain sensation. ASIC1a and ASIC3 are the ASIC subunits with the highest proton sensitivity. ASIC2a in contrast has low proton sensitivity but increases the variability of ASICs by forming heteromers with ASIC1a or ASIC3. ASICs are trimers and for the ASIC1a/2a heteromer it has been shown that subunits...

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Identifiers

PMID: 37422581
DOI: 10.1038/s42003-023-05087-4
PMCID: PMC10329638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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