Article
Proton binding sites involved in the activation of acid-sensing ion channel ASIC2a.
Neuroscience letters - 9 Oct 2007
Smith Ewan St J, Zhang Xuming, Cadiou Hervé, McNaughton Peter A
Abstract excerpt
Most acid-sensing ion channel (ASIC) subunits are activated by protons, but ASIC2b (a splice variant of ASIC2a) is acid-insensitive. Differences in protonatable residues between the extracellular loop regions of ASIC2a and ASIC2b may explain this difference. Site-directed mutagenesis, combined with immunocytochemistry and whole-cell patch clamp, demonstrated that mutating any one of five ASIC2a sites produces...
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