Article

Molecular and Functional Profiling of Gαi as an Intracellular pH Sensor

2024-04-30

Abstract excerpt

<title>Abstract</title> <p>Heterotrimeric G proteins (Gα, Gβ and Gγ) act downstream of G-protein-coupled receptors (GPCRs) to mediate signaling pathways that regulate various physiological processes and human disease conditions. Previously, human Gαi and its yeast homolog Gpa1 have been reported to function as intracellular pH sensors, yet the pH sensing capabilities of Gαi and the underlying mechanism remain to...

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Literature Corpus work: 2ff9ee36-b7b7-5fdb-8e3d-2d52dd302634
DOI: 10.21203/rs.3.rs-4203924/v1

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