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Article

Novel method to quantify phenotypic markers of HIV-associated neurocognitive disorder in a murine SCID model.

Journal of neurovirology - 1 Dec 2020

Gavegnano Christina, Haile Woldeab, Koneru Raj, Hurwitz Selwyn J, Kohler James J, Tyor William R, Schinazi Raymond F

Abstract excerpt

Despite combined antiretroviral therapy (cART), HIV infection in the CNS persists with reported increases in activation of macrophages (MΦ), microglia, and surrounding astrocytes/neurons, conferring HIV-induced inflammation. Chronic inflammation results in HIV-associated neurocognitive disorders (HAND) with reported occurrence of up to half of individuals with HIV infection. The existing HAND mouse model used by...

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Identifiers

PMID: 32901392
DOI: 10.1007/s13365-020-00842-3
PMCID: PMC7718289

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