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Bile Acid Sequestration by Colesevelam Reduces Bile Acid Hydrophobicity and Improves Liver Pathology in <em>Cyp2c70<sup>-/-</sup></em> Mice with a Human-Like Bile Acid Composition

2023-08-10

Abstract excerpt

Bile acids (BAs) and their signalling pathways have been identified as therapeutic targets for liver and metabolic diseases. We generated Cyp2c70-/- (KO) mice that are not able to convert chenodeoxycholic acid into rodent-specific muricholic acids (MCAs) and, hence, possess a more hydrophobic, human-like BA pool. Recently, we have shown that KO mice display cholangiopathic features with development of liver fibros...

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Literature Corpus work
0961b71b-18aa-503c-bc89-a6b27f7a6f27
DOI
10.20944/preprints202308.0779.v1
Open publication

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Bile Acid Sequestration by Colesevelam Reduces Bile Acid Hydrophobicity and Improves Liver Pathology in <em>Cyp2c70<sup>-/-</sup></em> Mice with a Human-Like Bile Acid CompositionDOI 10.20944/preprints202308.0779.v1
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