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Article

CYP3A deficiency alters bile acid homeostasis and leads to changes in hepatic susceptibility in rats.

Toxicology and applied pharmacology - 15 Oct 2021

Qin Xuan, Zhang Yuanjin, Lu Jian, Huang Shengbo, Liu Zongjun, Wang Xin

Abstract excerpt

Cytochrome P450 3A (CYP3A) as an important enzyme metabolizes many drugs and a variety of endogenous substances. Bile acids (BA) regulate physiological function by activating BA receptors. In this study, CYP3A1/2 gene knockout (KO) and wild-type (WT) rats were used to investigate the regulatory effects of CYP3A on BA homeostasis and liver function. Compared with WT rats, BA concentrations in serum, liver and...

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Identifiers

PMID: 34461081
DOI: 10.1016/j.taap.2021.115703

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