Article

Absence of muricholic acid due to Cyp2c-deficiency protects against high fat diet-induced obesity in male mice but promotes liver damage

2021-05-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Murine-specific muricholic acids (MCAs) are reported to protect against obesity and associated metabolic disorders. However, the response of mice with genetic depletion of MCA to an obesogenic diet has not been evaluated. We used Cyp2c-deficient (Cyp2c −/− ) mice, which lack MCAs and thus have a human-like bile acid (BA) profile, to directly investigate the potential role of...

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Literature Corpus work: 86aa4a3e-3805-5ac1-a232-17a3d042e9e4
DOI: 10.1101/2021.05.10.443487

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