Article
Liver-specific beta-catenin knockout mice exhibit defective bile acid and cholesterol homeostasis and increased susceptibility to diet-induced steatohepatitis.
The American journal of pathology - 1 Feb 2010
Behari Jaideep, Yeh Tzu-Hsuan, Krauland Lindsay, Otruba Wade, Cieply Benjamin, Hauth Beth, Apte Udayan, Wu Tong, Evans Rhobert, Monga Satdarshan P S
Abstract excerpt
Although the role of Wnt/beta-catenin signaling in liver growth and development is well established, its contribution in non-neoplastic hepatic pathologies has not been investigated. Here, we examine the role of beta-catenin in a murine model of diet-induced liver injury. Mice with hepatocyte-specific beta-catenin deletion (KO) and littermate controls were fed the steatogenic methionine and choline-deficient...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.