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Genetic ablation ofCyp8b1preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition

24 Oct 2017

Abstract excerpt

Both type 2 diabetes (T2D) and nonalcoholic steatohepatitis (NASH) are associated with reduced hepatic mitochondrial respiratory capacity. Cholic acid (CA) is the predominant 12α-hydroxylated bile acid that regulates hepatic lipid metabolism, and its circulating levels are negatively correlated with insulin resistance. Abolishing CA synthesis via the genetic disruption of the enzyme sterol 12α-hydroxylase (...

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PMID: 29066462
DOI: 10.1152/ajpendo.00172.2017

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