Cholestyramine Administration Induces Gut Dysbiosis and Severe Liver Injury in ApoE-/- Mice

Abstract excerpt

<title>Abstract</title> <p>Background & AimBile acids, as hydrophilicity/ hydrophobic molecules and natural ligands of bile acids receptors, are involved in the pathogenesis of liver injury and metabolic disorders. Cholestyramine acts as a bile acid chelating agent and is used to reduce cholesterol in clinic, but its hepatotoxicity and effects on metabolism are still unclear.MethodsApoE-/- mice were continuously...

Topics

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• Cholangiocarcinoma and Gallbladder Cancer Studies
• Diet and metabolism studies
• Diet, Metabolism, and Disease
• Drug Transport and Resistance Mechanisms
• Gut microbiota and health
• Liver Disease Diagnosis and Treatment
• Metabolomics and Mass Spectrometry Studies
• Pediatric Hepatobiliary Diseases and Treatments

Identifiers and source

Literature Corpus work

af21da91-bb9e-5c1a-8b5d-618b897d6ad3

DOI

10.21203/rs.3.rs-129379/v1