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Article

Of mice and men: murine bile acids explain species differences in the regulation of bile acid and cholesterol metabolism.

Journal of lipid research - 1 Apr 2020

Straniero Sara, Laskar Amit, Savva Christina, Härdfeldt Jennifer, Angelin Bo, Rudling Mats

Abstract excerpt

Compared with humans, rodents have higher synthesis of cholesterol and bile acids (BAs) and faster clearance and lower levels of serum LDL-cholesterol. Paradoxically, they increase BA synthesis in response to bile duct ligation (BDL). Another difference is the production of hydrophilic 6-hydroxylated muricholic acids (MCAs), which may antagonize the activation of FXRs, in rodents versus humans. We hypothesized...

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PMID: 32086245
DOI: 10.1194/jlr.RA119000307
PMCID: PMC7112145

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