Article
Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice.
Hepatology (Baltimore, Md.) - 1 Jul 2015
Slijepcevic Davor, Kaufman Christina, Wichers Catharina G K, Gilglioni Eduardo H, Lempp Florian A, Duijst Suzanne, de Waart Dirk R, Elferink Ronald P J Oude, Mier Walter, Stieger Bruno, Beuers Ulrich, Urban Stephan, van de Graaf Stan F J
Abstract excerpt
UNLABELLED: The Na(+) -taurocholate cotransporting polypeptide (NTCP) mediates uptake of conjugated bile acids (BAs) and is localized at the basolateral membrane of hepatocytes. It has recently been recognized as the receptor mediating hepatocyte-specific entry of hepatitis B virus and hepatitis delta virus. Myrcludex B, a peptide inhibitor of hepatitis B virus entry, is assumed to specifically target NTCP. Here,...
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