How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin.

Abstract excerpt

Influenza virus can escape most antibodies with single mutations. However, rare antibodies broadly neutralize many viral strains. It is unclear how easily influenza virus might escape such antibodies if there was strong pressure to do so. Here, we map all single amino-acid mutations that increase resistance to broad antibodies to H1 hemagglutinin. Our approach not only identifies antigenic mutations but also...

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• Share to Antibodies, Neutralizing
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• Share to Hemagglutinin Glycoproteins, Influenza Virus