Article

Structure basis for distinct protective mechanisms of IGHV3-23 antibodies targeting influenza hemagglutinin stem

2025-11-08

Abstract excerpt

<h4>ABSTRACT</h4> Characterization of antibodies targeting the conserved stem domain of influenza hemagglutinin (HA) is critical for developing broadly protective countermeasures against influenza virus. From a phage display human antibody library, this study discovers three group 1 HA-specific stem antibodies, namely HB31, HB34, and HB315, all of which are encoded by IGHV3-23. While HB31 and HB34 have minimal ne...

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Literature Corpus work: f6fd4a3d-30de-5e2e-89c0-c5b87c493beb
DOI: 10.1101/2025.11.06.687086

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