Article

Synaptic vesicle glycoprotein 2C enhances vesicular storage of dopamine and counters dopaminergic toxicity

2023-06-26

Abstract excerpt

Dopaminergic neurons of the substantia nigra exist in a persistent state of vulnerability resulting from high baseline oxidative stress, high energy demand, and broad unmyelinated axonal arborizations. Impairments in the storage of dopamine compound this stress due to cytosolic reactions that transform the vital neurotransmitter into an endogenous neurotoxicant, and this toxicity is thought to contribute to the do...

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Identifiers and source

Literature Corpus work: 09078ecd-de2e-56ad-abe1-2820099acd8b
DOI: 10.1101/2023.06.26.546143

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