Synaptojanin-1 supports VPS35-dependent trafficking of dopamine D2 autoreceptors at presynaptic terminals

Abstract excerpt

<title>Abstract</title> <p>Synaptic dysfunction is a hallmark of early Parkinson’s disease (PD), but molecular mechanisms underlying dopaminergic synaptic impairment and vulnerability remain poorly understood. Here, we identify a functional interaction between two PD genes, Synaptojanin1 and VPS35, in regulating endosomal sorting of the dopamine D2 short (D2S) autoreceptor, thereby modulating dopamine signaling....

Topics

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• Base Sequence
• Brain
• Genetic Markers
• Molecular Sequence Data
• Nerve injury and regeneration
• Neuroscience and Neuropharmacology Research
• Parkinson Disease
• Parkinson's Disease Mechanisms and Treatments

Identifiers and source

Literature Corpus work

200878b1-5dbd-5d6d-8fcb-5d7a644d0eeb

DOI

10.21203/rs.3.rs-7730224/v1