Article

Nicotine-mediated rescue of α-synuclein toxicity requires synaptic vesicle glycoprotein 2

2022-07-28

Abstract excerpt

<h4>Background</h4> Parkinson’s disease (PD) is characterized by α-synuclein aggregation and loss of dopamine (DA) neurons in the substantia nigra. Risk of PD arises due to a combination of genetic and environmental factors, which may interact, termed gene-environment (GxE) interactions. An inverse association between smoking and risk of PD is well-established, and a previous genome-wide GxE interaction study ide...

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Literature Corpus work: d571292f-99c3-5c27-93ad-75f046eef327
DOI: 10.1101/2022.07.26.501592

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