Article

Imaging Synaptic Vesicle Protein SV2C with <sup>18</sup> F-UCB-F: An In Vitro Autoradiography and In Vivo NHP PET Study

2026-03-10

Abstract excerpt

The synaptic vesicle protein SV2C, predominantly found in the basal ganglia, has been associated with Parkinson’s disease through genetic studies. It plays a crucial role in regulating dopamine release and has been shown to be disrupted in PD animal models and brain tissues from PD patients. In the context of PD-related synaptopathy, SV2C may serve as a potential imaging target for monitoring disease progression a...

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Literature Corpus work: 43b7c927-d0f5-5478-8974-e89eeab26e70
DOI: 10.64898/2026.03.08.710088

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