Article

Dopamine transporter and synaptic vesicle sorting defects initiate auxilin-linked Parkinson’s disease

2022-02-06

Abstract excerpt

<h4>SUMMARY</h4> Auxilin participates in the uncoating of clathrin-coated vesicles (CCVs), thereby facilitating synaptic vesicle (SV) regeneration at presynaptic sites. Auxilin ( DNAJC6 / PARK19 ) loss-of- function mutations cause early-onset Parkinson’s disease (PD). Here, we utilized auxilin-knockout (KO) mice to elucidate the mechanisms through which auxilin deficiency and clathrin-uncoating deficits lead to...

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Literature Corpus work: c10abb7c-6e7a-50b5-8ea1-450f06909ddf
DOI: 10.1101/2022.02.04.479203

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