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Article

Altered striatal dopamine levels in Parkinson's disease VPS35 D620N mutant transgenic aged mice.

Molecular brain - 1 Dec 2020

Vanan Sarivin, Zeng Xiaoxia, Chia Sook Yoong, Varnäs Katarina, Jiang Mei, Zhang Ke, Saw Wuan Ting, Padmanabhan Parasuraman, Yu Wei-Ping, Zhou Zhi-Dong, Halldin Christer, Gulyás Balázs, Tan Eng-King, Zeng Li

Abstract excerpt

Vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex that mediates the retrograde transport of cargo proteins from endosomes to the trans-Golgi network. Mutations such as D620N in the VPS35 gene have been identified in patients with autosomal dominant Parkinson's disease (PD). However, it remains poorly understood whether and how VPS35 deficiency or mutation contributes to PD...

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Identifiers

PMID: 33261640
DOI: 10.1186/s13041-020-00704-3
PMCID: PMC7706192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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