Article

Dopamine release from Parkinson’s patient-derived neurons is disrupted due to impaired synaptic vesicle loading

2026-03-13

Abstract excerpt

Striatal dopamine release defects are an early pathological feature observed in diverse models of Parkinson’s disease. However, the underlying molecular mechanisms responsible, and potential links to disease aetiology in humans, have been elusive. Here, we tested the hypothesis that dopamine release deficits are a characteristic feature of disease-relevant human neurons, using human Parkinson’s patient iPSC-derive...

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Literature Corpus work: 9570bec5-8fa1-5b7e-a775-da6e96a666bb
DOI: 10.64898/2026.03.11.711038

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