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Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy

1 May 2025

Abstract excerpt

Neurotransmitter release occurs through exocytosis of synaptic vesicles. α-Synuclein's function and dysfunction in Parkinson's disease and other synucleinopathies is thought to be tightly linked to synaptic vesicle binding. Age is the biggest risk factor for synucleinopathy, and ~15% of synaptic vesicle proteins have been linked to central nervous system diseases. Yet, age- and disease-induced changes in synaptic...

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PMID: 40312501
DOI: 10.1038/s41467-025-59441-7

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