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Article

Kras and Tp53 Mutations Cause Cholangiocyte- and Hepatocyte-Derived Cholangiocarcinoma.

Cancer research - 15 Aug 2018

Hill Margaret A, Alexander William B, Guo Bing, Kato Yasutaka, Patra Krushna, O'Dell Michael R, McCall Matthew N, Whitney-Miller Christa L, Bardeesy Nabeel, Hezel Aram F

Abstract excerpt

Intrahepatic cholangiocarcinoma (iCCA) is a primary liver cancer epidemiologically linked with liver injury, which has poorly understood incipient stages and lacks early diagnostics and effective therapies. While iCCA is conventionally thought to arise from the biliary tract, studies have suggested that both hepatocytes and biliary cells (cholangiocytes) may give rise to iCCA. Consistent with the plasticity of...

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Source

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Identifiers

PMID: 29871934
DOI: 10.1158/0008-5472.CAN-17-1123
PMCID: PMC6097629

Genes

SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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