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A developmental biliary lineage program cooperates with Wnt activation to promote cell proliferation in hepatoblastoma

20 Nov 2024

Abstract excerpt

Cancers evolve not only through the acquisition and clonal transmission of somatic mutations but also by epigenetic mechanisms that modify cell phenotype. Here, we use histology-guided and spatial transcriptomics to characterize hepatoblastoma, a childhood liver cancer that exhibits significant histologic and proliferative heterogeneity despite clonal activating mutations in the Wnt/β-catenin pathway. Highly...

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PMID: 39567523
DOI: 10.1038/s41467-024-53802-4

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