Article

Co-repression of <i>Yap1</i> and <i>Sox9</i> Abrogates Established Cholangiocarcinoma by Eliminating Transcriptional Compensation

2026-02-02

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background/Aims</h4> Intrahepatic cholangiocarcinoma (iCCA) represents an unmet clinical need due to its increasing incidence, aggressive biology, and limited treatment options. The extremely low-response rates to current systemic regimens and the emergence of adaptive resistance to targeted therapies underscore the urgent need for alternative therapeutic strategies. Given that the lineage-...

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Literature Corpus work: 85af9fb8-840d-5994-88c0-d958d3c0add9
DOI: 10.64898/2026.01.30.702953

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