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Article

NOTCH-YAP1/TEAD-DNMT1 Axis Drives Hepatocyte Reprogramming Into Intrahepatic Cholangiocarcinoma

9 May 2022

Abstract excerpt

BACKGROUND & AIMS: Intrahepatic cholangiocarcinoma (ICC) is a devastating liver cancer with extremely high intra- and inter-tumoral molecular heterogeneity, partly due to its diverse cellular origins. We investigated clinical relevance and the molecular mechanisms underlying hepatocyte (HC)-driven ICC development. METHODS: Expression of ICC driver genes in human diseased livers at risk for ICC development were...

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Share to Cholangiocarcinoma and Gallbladder Cancer Studies
Share to Hippo pathway signaling and YAP/TAZ
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PMID: 35550144
DOI: 10.1053/j.gastro.2022.05.007

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