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Natural and Experimental Rewiring of Gene Regulatory Regions.

Annual review of genomics and human genetics - 31 Aug 2022

Downes Damien J, Hughes Jim R

Abstract excerpt

The successful development and ongoing functioning of complex organisms depend on the faithful execution of the genetic code. A critical step in this process is the correct spatial and temporal expression of genes. The highly orchestrated transcription of genes is controlled primarily by cis-regulatory elements: promoters, enhancers, and insulators. The medical importance of this key biological process can be...

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PMID: 35472292
DOI: 10.1146/annurev-genom-112921-010715

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