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Mitochondrial oxidation of the carbohydrate fuel driven by pyruvate dehydrogenase robustly enhances stemness of older and geriatric Intestinal Stem Cells

2024-09-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and Aims</h4> Aging impairs Intestinal Stem Cell (ISC) function and attenuates their regenerative capacity. Although the transcriptional landscape governing ISC fate during aging has been described, almost nothing is known about how metabolite handling regulates ISC renewal and maintains stemness. We investigated how mitochondrial metabolism of glucose and fatty acid-derived carb...

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Literature Corpus work
08c2c072-47e1-570c-80f2-10d2989b7186
DOI
10.1101/2024.09.23.614374
Open publication

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Mitochondrial oxidation of the carbohydrate fuel driven by pyruvate dehydrogenase robustly enhances stemness of older and geriatric Intestinal Stem CellsDOI 10.1101/2024.09.23.614374
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