Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism.

doi:10.1038/ncb3593

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Article

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism.

Nature cell biology - 1 Sept 2017

Schell John C, Wisidagama Dona R, Bensard Claire, Zhao Helong, Wei Peng, Tanner Jason, Flores Aimee, Mohlman Jeffrey, Sorensen Lise K, Earl Christian S, Olson Kristofor A, Miao Ren, Waller T Cameron, Delker Don, Kanth Priyanka, Jiang Lei, DeBerardinis Ralph J, Bronner Mary P, Li Dean Y, Cox James E, Christofk Heather R, Lowry William E, Thummel Carl S, Rutter Jared

Abstract excerpt

Most differentiated cells convert glucose to pyruvate in the cytosol through glycolysis, followed by pyruvate oxidation in the mitochondria. These processes are linked by the mitochondrial pyruvate carrier (MPC), which is required for efficient mitochondrial pyruvate uptake. In contrast, proliferative cells, including many cancer and stem cells, perform glycolysis robustly but limit fractional mitochondrial...

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PMID: 28812582
DOI: 10.1038/ncb3593
PMCID: PMC6137334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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