Article
Metabolic determination of cell fate through selective inheritance of mitochondria.
Nature cell biology - 1 Feb 2022
Döhla Julia, Kuuluvainen Emilia, Gebert Nadja, Amaral Ana, Englund Johanna I, Gopalakrishnan Swetha, Konovalova Svetlana, Nieminen Anni I, Salminen Ella S, Torregrosa Muñumer Rubén, Ahlqvist Kati, Yang Yang, Bui Hien, Otonkoski Timo, Käkelä Reijo, Hietakangas Ville, Tyynismaa Henna, Ori Alessandro, Katajisto Pekka
Abstract excerpt
Metabolic characteristics of adult stem cells are distinct from their differentiated progeny, and cellular metabolism is emerging as a potential driver of cell fate conversions1-4. How these metabolic features are established remains unclear. Here we identified inherited metabolism imposed by functionally distinct mitochondrial age-classes as a fate determinant in asymmetric division of epithelial stem-like...
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