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Regulation of Mitochondrial Quality Control of Intestinal Stem Cells in Homeostasis and Diseases

3 Sept 2024

Abstract excerpt

Significance: Intestinal stem cells (ISCs) are crucial for the continuous renewal and regeneration of the small intestinal epithelium. ISC fate decisions are strictly controlled by metabolism. Mitochondria act as the central hubs of energetic metabolism and dynamically remodel their morphology to perform required metabolic functions. Mitochondrial dysfunction is closely associated with a variety of...

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PMID: 39225500
DOI: 10.1089/ars.2023.0489

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