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Metabolic Rewiring and Stemness: A Critical Attribute of Pancreatic Cancer Progression

4 Mar 2023

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive diseases with a poor 5-year survival rate. PDAC cells rely on various metabolic pathways to fuel their unlimited proliferation and metastasis. Reprogramming glucose, fatty acid, amino acid, and nucleic acid metabolisms contributes to PDAC cell growth. Cancer stem cells are the primary cell types that play a critical role in the progression and...

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PMID: 36869789
DOI: 10.1093/stmcls/sxad017

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