Article

Design and characterisation of mutant and wild-type huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems

2018-12-10

Abstract excerpt

<h4>ABSTRACT</h4> The gene mutated in Huntington’s disease (HD) patients encodes the 348 kDa huntingtin (HTT) protein. The pathogenic HD CAG-expansion mutation causes a polyglutamine (polyQ) tract at the N-terminus of the HTT protein to expand above a critical threshold of ~35 glutamine residues. The effect of HD mutations on HTT is not well understood, in part due to difficulties in carrying out biochemical, bio...

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Literature Corpus work: 088b6bee-9c80-566c-b9b9-a751ecbd3c3d
DOI: 10.1101/492215

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