Article

High-Affinity, Structure-Validated and Selective Macrocyclic Peptide Tools for Chemical Biology Studies of Huntingtin

2025-08-06

Abstract excerpt

Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion in the Huntingtin ( HTT ) gene, with no disease-modifying therapies currently available. The precise molecular function of the HTT protein is unclear, and the lack of selective chemical tools has limited functional studies. We have identified and characterized macrocyclic peptide binders targeting HTT. These binders...

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Literature Corpus work: c4fb93bc-9112-5f7b-97d8-5d56a2f8f1f9
DOI: 10.1101/2025.08.06.668955

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