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pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking

1 Jun 2010

Abstract excerpt

BACKGROUND: Huntingtin (htt) is a multi-domain protein of 350 kDa that is mutated in Huntington's disease (HD) but whose function is yet to be fully understood. This absence of information is due in part to the difficulty of manipulating large DNA fragments by using conventional molecular cloning techniques. Consequently, few studies have addressed the cellular function(s) of full-length htt and its...

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PMID: 20515468
DOI: 10.1186/1756-6606-3-17

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