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Article

Scalable production in human cells and biochemical characterization of full-length normal and mutant huntingtin.

PloS one - 1 Jan 2015

Huang Bin, Lucas Tanja, Kueppers Claudia, Dong Xiaomin, Krause Maike, Bepperling Alexander, Buchner Johannes, Voshol Hans, Weiss Andreas, Gerrits Bertran, Kochanek Stefan

Abstract excerpt

Huntingtin (Htt) is a 350 kD intracellular protein, ubiquitously expressed and mainly localized in the cytoplasm. Huntington's disease (HD) is caused by a CAG triplet amplification in exon 1 of the corresponding gene resulting in a polyglutamine (polyQ) expansion at the N-terminus of Htt. Product...

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Identifiers

PMID: 25799558
DOI: 10.1371/journal.pone.0121055
PMCID: PMC4370734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25799558-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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