Article

Developmental and physiological impacts of pathogenic human huntingtin protein in the nervous system

2024-09-02

Abstract excerpt

Huntington’s Disease (HD) is a neurodegenerative disorder, part of the nine identified inherited polyglutamine (polyQ) diseases. Most commonly, HD pathophysiology manifests in middle-aged adults with symptoms including progressive loss of motor control, cognitive decline, and psychiatric disturbances. Associated with the pathophysiology of HD is the formation of insoluble fragments of the huntingtin protein (htt)...

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Literature Corpus work: 4ef4304b-54c8-5c49-9952-d544c304b258
DOI: 10.1101/2024.08.30.610525

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