Article

PolyQ expansion does not alter the Huntingtin-HAP40 complex

2021-02-02

Abstract excerpt

<h4>Summary</h4> The abnormal amplification of a CAG repeat in the gene coding for huntingtin (HTT) leads to Huntington disease (HD). At the protein level, this translates into the expansion of a poly-glutamine (polyQ) stretch located at the HTT N-terminus, which renders it aggregation-prone by unknown mechanisms. Here we investigated the effects of polyQ expansion on HTT in a complex with its stabilizing interac...

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Literature Corpus work: 41334c0d-2a78-5f25-8ff2-018e0e7749dd
DOI: 10.1101/2021.02.02.429316

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